Adverse effects were observed through the presence of hypercalcemia/hypercalciuria. All others studied vitamin D mega-dose versus placebo. Two studies compared the exact dosage of vitamin D by different routes of administration, and three studies compared different doses by the same route.

Of the 59 articles screened for this review, 10 were included in the review, studying patients with rickets, osteoporosis, and critically ill patients. CONSORT questionnaire was used to assess the quality of the included studies. This is a systematic review of the literature searching data through the electronic banks of PubMed, Scielo, and LILACS, using the following keywords: 'vitamin D,' 'mega-dose,' 'stoss therapy,' 'cholecalciferol,' in different combinations. To carry out a literature review on safety and efficacy (normalization of serum vitamin D level, and changes in the clinical picture) of vitamin D mega-dose use.

In this sense, conducting a review to organize this knowledge in a single article will generate a helpful instrument for researchers working in this area and for health professionals who use this therapeutic tool. Supplementation with high doses of vitamin D, known as mega-dose or 'stoss therapy,' refers to administering high doses of vitamin D by oral or intramuscular route in short periods of time.

Megasync safe